Description
Nous recrutons un.e étudiant.e de Master 2 pour un projet de développement de méthode d'analyse par imagerie par spectrométrie de masse (MALDI-ToF et MALDI-FTICR) sur des tissus de plantes appartenant au genre Plectranthus.
Le stage débutera en janvier-février 2026, au sein de l'institut CARMeN (anciennement Laboratoire COBRA) sur le site de Mont Saint Aignan et sera encadré par Mathilde Lauzent, Guillaume Hamion et moi-même.
Pour en savoir plus, je vous invite à lire l'offre en attaché. N'hésitez pas à la diffuser auprès des étudiant.e.s que ce sujet pourrait intéresser.
Date limite de candidature : 23/10/2025
Le groupe de chimie analytique du Laboratoire de Chimie Moléculaire (UMR 9168, Ecole Polytechnique) a obtenu un financement PEPR B-Best dans le cadre du projet Amaretto. Ce projet vise à la caractérisation de la biomasse par imagerie par spectrométrie de masse à très haute résolution pour identifier des marqueurs de réactivité de l'hydrolyse enzymatique. La mission consistera à réaliser les analyses chimiques, leur interprétation et leur mise en forme pour le traitement chemo-informatique des données.
Plus d’informations : https://emploi.cnrs.fr/Offres/CDD/UMR9168-DAVTOU-003/Default.aspx
Date limite de candidature : 1er Octobre 2025
Bioanalysis of Antibody-Drug Conjugates (ADCs) using Mass Spectrometry (for details, see attached pdf)
Description du poste
Our research group possesses extensive expertise in developing innovative chromatographic methods for the characterization of a wide range of biopharmaceutical products, which are highly popular today in the pharmaceutical industry. These include mAbs, ADCs, bispecific antibodies, oligonucleotides (ASO, SiRNA), oligonucleotide-mAb conjugates, gene therapy products (AAVs), and mRNA vaccines. The objective of the postdoctoral position is to integrate these advanced chromatographic techniques with high-resolution mass spectrometry (QqTOF/MS) to identify synthesis-related impurities, degradation products, post-translational modifications. The postdoc will be expected to both collaborate with PhD students and other postdocs on specific biopharmaceutical research challenges requiring MS analysis, while also developing independent research lines in the field of LC-MS applied to large biomolecules. Project samples will be sourced through collaborations with industrial partners. The work will involve a balanced combination of theoretical investigation and practical application.
Our research group possesses extensive expertise in developing innovative chromatographic methods for the characterization of a wide range of biopharmaceutical products, which are highly popular today in the pharmaceutical industry. These include mAbs, ADCs, bispecific antibodies, oligonucleotides (ASO, SiRNA), oligonucleotide-mAb conjugates, gene therapy products (AAVs), and mRNA vaccines. The objective of the postdoctoral position is to integrate these advanced chromatographic techniques with high-resolution mass spectrometry (QqTOF/MS) to identify synthesis-related impurities, degradation products, post-translational modifications. The postdoc will be expected to both collaborate with PhD students and other postdocs on specific biopharmaceutical research challenges requiring MS analysis, while also developing independent research lines in the field of LC-MS applied to large biomolecules. Project samples will be sourced through collaborations with industrial partners. The work will involve a balanced combination of theoretical investigation and practical application.